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Title:: Micro-injection based Technology for Preparation of Drug ?Delivery Coating on Titanium Alloy

Author(s):: SUN Bo1; SUN Huaiyuan1; 2; SONG Xiaokang1; LIU Zhiqiang1; 1.University of Shanghai for Science and Technology, Shanghai 200093, China;2.Shanghai University Of Medicine & Health Sciences, Shanghai 200093

Keywords:: Micro-injection; Drug-loaded coating; Drug release; Poly(lactic-co-glycolic acid); Triclosan

摘要:: 为了探究微喷技术在钛合金表面制备载药涂层的应用，采用数字化微喷系统在钛合金片表面制备含抗生素三氯生的聚乳酸-羟基乙酸(poly(lactic-co-glycolic acid)，PLGA)涂层。通过控制主要参数变量电压和频率，探究喷射参数对喷射过程的影响，进而优化喷射参数，制备载药涂层。采用扫描电子显微镜（SEM）观测涂层表面,评价其形貌特征；将制备的载药涂层置于PBS缓冲液中进行体外模拟释放实验，分析数据并绘制药物释放曲线。结果表明，数字化微喷技术应用于载药涂层制备方面具备可行性，通过控制喷射参数，获得了表面均匀、平滑的载药涂层，并且涂层的药物释放曲线也表明，该涂层的药物释放能够达到有效抑菌浓度范围。

Abstract:: In order to explore the application of micro-injection technology in the preparation of the coating on titanium alloy surface, the poly(lactic-co-glycolic acid ) coating containing triclosan was prepared on the surface of the titanium alloy by digital micro-injection system. The influence of injection parameters was studied by controlling the main parameters of voltage and frequency. The drug loaded coating was prepared with the injection parameters which were optimized. The scanning electron microscopy (SEM) was used to observe the morphology of the coating, and to verify if the surface could meet the requirements. The drug loaded coating was placed in the PBS buffer for the vitro release experiments . And then the data were analyzed and the drug release curve was drawn. The results show that the digital micro-injection technology is feasible to prepare the drug delivery coating. The uniform and smooth coating can be obtained by adjusting the injection parameters. And the drug release curve also show that the concentration of drug reaches the effective range of inhibition.