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Title:: Experimental study in mice on the technology of transcranial magneto-acoustic coupling electrical stimulation

Author(s):: LIU Shikun; ZHANG Xinshan; ZHOU Xiaoqing; YIN Tao; LIU Zhipeng; Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China

Keywords:: Transcranial magneto-acoustic stimulation; Electrical nerve stimulation; Parkinson′s disease model; In vivo animal experiments; Behavioral assays; Field excitatory postsynaptic potential(fEPSP)

摘要:: 研究经颅磁声耦合刺激技术（transcranial magneto-acoustic stimulation, TMAS）在体小动物脑神经刺激效果。搭建了针对小动物模型的TMAS系统。设置TMAS系统参数，对健康鼠及帕金森（parkinson′s disease，PD）模型鼠进行经颅聚焦磁声刺激实验，并分析行为学及电生理结果。经过TMAS刺激后，行为学结果表明磁声刺激组小鼠在主动探索学习能力和运动能力显著高于对照组；电生理结果表明TMAS刺激后PD模型鼠海马区黑质神经突触活性提高。实验结果验证了TMAS技术对小鼠脑神经刺激的有效性。该技术的进一步研究将具有更好的应用前景。

Abstract:: To investigate the effects of transcranial magneto-acoustic stimulation（TMAS）on the cranial nerve of the small animals（mice）. The TMAS system for the small animals was set up,and the TMAS was applied to small animals in vivo. The healthy mice and the mice with Parkinson′s disease（PD） were adopted in the experiment, and the behavioral and electrophysiological data were recorded and analyzed.After simulated by TMAS, the behavioral results illustrated that the motor function and learning ability of TAMS group had been improved obviously than that of the control group. The electrophysiological results depicted that the synaptic activity of the substantia nigra of PD mice had been promoted. These encouraging in vivo mouse experimental results suggest that the TMAS technique is effective on the brain stimulation,which might someday be put to good use.