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Title:: Fabrication method and compressive property of surface-porous ?polyetheretherketone (PEEK)：an optimal interbody fusion material

Author(s):: ZHANG Yunxia; LI Qiuyan; WANG Dong; HE Guo; College of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China

Keywords:: Poly ether ether ketone; Surface porous material; Interbody fusion; Compressive property; High load-bearing condition

摘要:: 为了满足聚醚醚酮（poly ether ether ketone，PEEK）融合器在高应力环境下的应用，同时提高其与骨组织的接合能力，采用压铸和腐蚀方法制备孔径为0.4 mm, 多孔层厚度为1.5 mm，开孔率达100%的表面多孔PEEK(surface porous-PEEK，SP-PEEK)，并研究了SP-PEEK的单向压缩行为。结果显示：当SP-PEEK孔隙率分别为30%，40%和50%时，其在横向力（平行于多孔层方向）作用下，保留了实体PEEK 53.6%~83.6%的弹性模量（分别为9.2、7.9和5.9 GPa）及87.1%~90.5%的屈服强度（分别为57、55.8和54.9 MPa）；在轴向力（垂直于多孔层方向）作用下，SP-PEEK保留了47.1%~49.1%的弹性模量（分别为5.4、5.3和5.2 GPa）及64.3%~79%的屈服强度（分别为49.8、48.3和40.5 MPa）。制备的SP-PEEK具有与皮质骨相当的弹性模量（4.9~28 GPa），能够满足脊柱融合的刚度要求。

Abstract:: In order to improve interface integration between bone and poly ether ether ketone(PEEK) cage, PEEK was modified with a surface porous layer by die casting and etching process. Porous layer with 100% open porosity possessed a pore size of 400 μm and thickness of 1.5 mm. Under transverse force (parallel to porous layer), uni-axial compression tests showed that surface porous PEEK (SP-PEEK) with porosities of 30%, 40% and 50%preserved 87.1%~90.5% of the strength (57, 55.8 and 54.9 MPa respectively)and 53.6%~83.6% of the elastic modulus (9.2, 7.9 and 5.9 GPa respectively) of solid injection-molded PEEK.Under axial force (perpendicular to porous layer), SP-PEEK with porosities of 30%, 40% and 50%preserved 64.3%~79% of the compressive yield strength (49.8, 48.3 and 40.5 MPa respectively) and 47.1%~49.1% of the elastic modulus (5.4, 5.3 and 5.2 GPa respectively) of solid PEEK. As-prepared SP-PEEK possessed comparable stiffness with cortical bone (4.9~28 GPa), suggesting that SP-PEEK can maintain stiffness necessary for interbody fusion.