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Title:: Study on preparation and properties of polylactic acid-hyaluronic acid composite membranes

作者:: 李俊起; 王宪朋△; 刘阳; 朱爱臣; 王传栋; 王勤; 马丽霞; 董浩; 山东省药学科学院山东省医用高分子材料重点实验室，济南 250101

Author(s):: LI Junqi; WANG Xianpeng; LIU Yang; ZHU Aichen; WANG Chuandong; WANG Qin; MA Lixia; DONG Hao; Shandong Academy of Pharmaceutical Scicences,Shandong Provincial Key Laboratory of Biomedical Polymers,Jinan 250101,China

Keywords:: Polylactic acid; Electrospinning; Hyaluronic acid; Plasma; Mechanical properties

摘要:: 以疏水性聚乳酸为原料，采用静电纺丝工艺制备得到纤维膜，通过等离子体表面处理技术将亲水性透明质酸与纤维膜结合，制备得到聚乳酸-透明质酸复合膜。采用扫描电镜、接触角测量仪和万能拉力机对复合膜的表面纤维形貌、接触角、力学性能等进行了表征。结果表明,聚乳酸纺丝的最佳电压为15~20 kv，随纺丝液浓度的增大，纤维膜的力学性能得以提高，等离子体处理时间为8 min时，得到的复合膜具有较好的亲水性。

Abstract:: The fiber membranes of polylactide acid were prepared by electrospinning,and then were combined with the hydrophilic hyaluronic acid (HA) by plasma surface treatment technology to prepare the PLA-HA composite membranes.The fiber morphology on the surface,contact angle and mechanical properties of the composite membranes were characterized by scanning electron microscopy,contact angle measuring instrument and tensile testing machine,respectively.The results show that the optimal spinning voltage of PLA is between 15 kv and 20 kv.With the increase of spinning solution concentration, the mechanical properties of the fiber membranes are improved. When the plasma treatment time is 8 min, the hydrophilicity of composite membranes is enhanced.