文章摘要

文章信息/Info

Author(s):: HUANG Feng; ZHU Zhuoling; College of Metrology & Measurement Engineering, China Jiliang University, Hangzhou 310000，China

Keywords:: Mock loop; Blood pump; Ventricular assist device; Artificial heart; In vitro evaluation

摘要:: 心室辅助血泵已经成为临床上治疗终末期心力衰竭的一种重要手段。在心室辅助血泵的研发过程中，模拟血液循环回路试验作为动物实验的重要补充，已经成为其不可或缺的试验工具。模拟循环回路通过模拟人体血液循环系统各部分的主要特征，建立与真实血液循环系统相似的宏观血流动力学环境，从而为心室辅助血泵提供与植入人体后相似的工作环境。模拟循环回路可完成血泵的基本水力性能、辅助血液循环的能力以及长期稳定性和可靠性等体外评估，还能够作为血泵生理控制实验的平台，具有多样化的功能。我们对近年来国内外的模拟循环回路发展状况和趋势进行介绍，为该领域内的进一步研究提供参考。

Abstract:: Ventricular assist blood pumps have become an important clinical method for the end-stage heart failure treatment. As an important supplement of the animal trials, in vitro evaluation on a mock blood circulatory loop has been proven its effectiveness during the developing of blood pumps. A mock loop simulates the main characteristics of the human blood circulatory system to establish a macro hemodynamic environment similar to the real blood circulation system, providing a work environment similar to where the implanted the blood pump connects. The mock loop can test the basic hydraulic performance, the assisting capability and the long-term stability and reliability of blood pumps in vitro. Furthermore, it can also be a good platform for the physiological control experiment of blood pumps. We review the recent development and trend of the mock circulatory loops to give a comprehensive reference for the further researches in this field.