[1]马丽霞,吴倩倩,董浩,等.生物可降解聚酯乙交酯丙交酯共聚物中溶剂残留测定*[J].生物医学工程研究,2019,04:481-484.
MA Lixia,WU Qianqian,DONG Hao,et al.Determination of residual solvents in biodegradable poly(lactide-co-glycolide)[J].Journal of Biomedical Engineering Research,2019,04:481-484.
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生物可降解聚酯乙交酯丙交酯共聚物中溶剂残留测定*(PDF)
《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
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2019年04期
- 页码:
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481-484
- 栏目:
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- 出版日期:
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2019-12-25
文章信息/Info
- Title:
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Determination of residual solvents in biodegradable poly(lactide-co-glycolide)
- 文章编号:
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1672-6278 (2019)04-0481-04
- 作者:
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马丽霞; 吴倩倩; 董浩; 刘阳△; 朱爱臣; 王宪朋; 李俊起; 王传栋; 王勤
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山东省药学科学院 山东省医用高分子材料重点实验室,济南 250101
- Author(s):
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MA Lixia; WU Qianqian; DONG Hao; LIU Yang; ZHU Aichen; WANG Xianpeng; LI Junqi; WANG Chuandong; WANG Qin
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Shandong Academy of Pharmaceutical Sciences, Shandong Provincial Key Laboratory of Biomedical Polymers, Jinan 250101, China
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- 关键词:
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顶空气相色谱法; 毛细管柱; 生物可降解聚酯; 乙交酯丙交酯共聚物; 溶剂残留
- Keywords:
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Headspace gas chromatography; Capillary column; Biodegradable polyester; Poly(lactide-co-glycolide); Residual solvents
- 分类号:
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R318
- DOI:
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10.19529/j.cnki.1672-6278.2019.04.20
- 文献标识码:
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A
- 摘要:
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采用DB-624(30 m×530 μm×3.0 μm)毛细管色谱柱,氢火焰离子化检测器(FID),顶空进样,建立了乙交酯丙交酯共聚物(PLGA)中残留溶剂测定方法。试验结果表明,该方法测得各溶剂在考察浓度范围内峰面积与质量浓度呈现良好的线性关系,回收率在98.54%~99.50%,精密度RSD均小于2%,定量限在0.16~1.17 μg/mL。本方法操作简单、结果准确、重现性好,可用于PLGA中乙醇、丙酮、二氯甲烷和乙酸乙酯残留溶剂的同时测定。
- Abstract:
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A headspace gas chromatography method was established for the determination of residual solvents in poly(lactide-co-glycolide) . The method was programmed with DB-624 capillary column (30m×530 μm×3.0 μm) and flame ionization detector (FID). The results showed that the standard curves were linear in the range of experimental concentration, the average recoveries for four residual solvents were between 98.54% and 99.50%, the RSDs of precision was all less than 2%, the quantitation limits were 0.16 μg/ml~1.17 μg/ml. The method is rapid, sensitive and accurate. It can be used for the determination of ethanol, acetone, dichloromethane and acetic ether in poly(lactide-co-glycolide) at the same time.
备注/Memo
- 备注/Memo:
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(收稿日期:2019-05-21)山东省重点研发计划项目(2017GSF18168,2018GSF118132)。△通信作者Email:13854160830@163.com
更新日期/Last Update:
2020-01-06