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Title:: Study on the characteristics of pneumatic injection device based on microfluidic chip

Author(s):: GUO Wanxing; XU Xiulin; School of Medical Instrument and Food Engineering，University of Shanghai for Science and Technology，Shanghai 200093，China

Keywords:: Microfluidic chip; Sorting; Pressure driven; Injection system; Simulink simulation

摘要:: 为了精准控制微流控芯片的分选进样速度，本研究设计了一种气压控制的进样系统。通过PID闭环控制，实现了对缓冲溶液瓶中气体容腔的精准压力控制,将样液以平稳的流量推送入微流控芯片中。采用Matlab软件中的Simulink建立数学模型对进样系统仿真，获得了在不同流量信号输入时，微流道中液体流量的动态响应特性。通过对比实验,仿真结果中进样系统达到输出稳定的时间不超过70 ms，稳定误差为3%；实验结果中进样系统达到输出稳定的时间不超过75 ms，稳定误差为5%，实验结果与仿真结果呈现高度正相关。

Abstract:: To accurately control the sorting injection speed of microfluidic chip, we designed a pneumatic injection system.Through PID closed-loop control, the precise pressure control of the gas chamber in the buffer solution bottle was realized, and the sample solution was pushed into the microfluidic chip with a steady flow rate.Simulink of Matlab software was adopted to establish the mathematical model of sampling system simulation,and obtain the dynamic response characteristics of liquid flow in microchannel with different flow signals.Through contrast experiment,the stable errorin simulation results was 3%,the sampling system achieve stabled output was no more than 70 ms;and the stable error inexperimental results was 5%, the sampling system achieved stable output time was not more than 75 ms.The experimental results and simulation results show highly positive correlation.