文章摘要

文章信息/Info

作者:: 许蓬娟1; 于志超2; 褚晓倩1; 高静1; 谭俊珍1△; 1.天津中医药大学中西医结合学院，天津 301617；2.天津中德应用技术大学科研处，天津 300350

Author(s):: XU Pengjuan1; YU Zhichao2; CHU Xiaoqian1; GAO Jing1; TAN Junzhen1; 1.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China；2.Office of Academic Research, Tianjin Sino-German University of Applied Sciences, Tianjin 300350

Keywords:: Nanosized particles; Nanotoxicology; Health and environmental effects; Autophagy pathway; Review

摘要:: 随着纳米技术的飞速发展，纳米材料凭借其特殊的理化性质被广泛应用于各个领域。近年来，纳米材料的毒性作用引起人们的高度关注。但目前对纳米材料详细毒理机制的认识，尤其是与扮演细胞“清道夫”角色的自噬途径的关系仍较为有限。据此，我们总结了纳米毒性作用与自噬途径的关系及其潜在意义，以期能够为纳米材料的进一步发展与应用有所启示，使纳米科技可以更安全的发展。

Abstract:: With rapid development of nanotechnology, many nanoparticles have been widely used in a variety of applications. In recent years, the toxicity of nanoparticles has attracted great attention.However, the current understanding of the detailed toxicological mechanism of nanomaterials, especially the relationship with the autophagy pathway that plays the role of cell "scavenger" is still relatively limited. Based on this, we review the relationship between nano-toxicity and autophagy pathway and its potential significance, to provide enlightenment for the further development and application of nanomaterials, so that nanotechnology can develop more safely.