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Title:: Experimental study on bipolar radio frequency lipolysis on cooling conditions

Author(s):: SUN Tingting; GE Xiaoli; WANG Binyu; AN Junrui; WANG Jianjun; ZHOU Yu; College of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China

Keywords:: Radio frequency; Fat dissolution; Temperature control; Cooling system; Heating up time; Interaction depth; Efficiency

摘要:: 为实现有效溶脂、提高溶脂效率，本研究在无创双极射频溶脂设备的基础上，将外用器械头改良为冷却式作用器械头，并加入冷却装置，选取45 ℃、50 ℃和55 ℃三个控制温度进行有、无冷却条件的温控射频溶脂实验，每次实验15 min，用红外热成像仪拍摄横断面温度分布图，并用K型热电偶采集温度数据进行评估分析。结果显示，45 ℃、50 ℃和55 ℃下的有效溶脂区域深度分别从无冷却条件下的(5.3±0.29) mm、(6.43±0.39) mm、(8.2±0.28) mm增加至有冷却条件下的(5.45±0.44) mm、(6.9±0.46) mm、(8.38±0.35) mm，脂肪组织达到凋亡阈值温度的所需时间分别从无冷却条件下的(13.67±2.42) min、(6.5±3.45) min、(2.7±0.63) min缩短至有冷却条件下的(11.17±3.01) min、(3.67±0.82) min、(1.83±0.41) min。改良后的设备能使射频能量更深入脂肪层，同时可缩短升温时间，提高溶脂效率。

Abstract:: Based on the noninvasive bipolar radio frequency(RF) lipolysis equipment, we improved the external instrument head to a cooling instrument head, added a cooling device to improve the fat dissolution efficiency on the premise of effective fat dissolution. Temperature controlled RF fat dissolving experiments with or without cooling conditions were carried out at three control temperatures of 45 ℃, 50 ℃ and 55 ℃. Each experiment lasted for 15 min. The cross-sectional temperature distribution was taken by infrared thermal imager and the temperature data were collected by K-type thermocouple for evaluation and analysis. The results showed that the depth of effective fat dissolution area at 45 ℃, 50 ℃ and 55 ℃ increased from (5.3±0.29) mm, (6.43±0.39) mm and (8.2±0.28) mm without cooling conditions to (5.45±0.44) mm, (6.9±0.46) mm and (8.38±0.35) mm under coolingconditions respectively. The time required for adipose tissue to reach the apoptosis threshold temperature decreased from (13.67±2.42) min, (6.5±3.45) min and (2.7±0.63) min without cooling conditions to (11.17±3.01) min, (3.67±0.82) min and (1.83±0.41) min under coolingconditions respectively. The improved device can make the RF energy deeper into the fat layer, shorten the heating time and improve the efficiencyof lipolysis.