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Title:: Research progress on electrospun fibrous scaffold for scarring prevention

作者:: 崔奎琰1; 汪丽燕1; 杨光1; 钟文2; 彭新生1; 周郁斌1△; 陈慧芝1△; 1.广东医科大学广东天然药物研究与开发重点实验室，药学院东莞 523808；2.陆军第75集团军医院皮肤病科，大理 671000

Author(s):: CUI Kuiyan1; WANG Liyan1; YANG Guang1; ZHONG Wen2; PENG Xinsheng1; ZHOU Yubin1; CHEN Huizhi1; 1. Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan 523808，China;2. Department of Dermatological, the 75th Army Hospital of PLA, Dali 671000，China

Keywords:: Electrospinning; Wound dressing; Nanofibers; Scarring; Durg-loaded system; Biomaterials

摘要:: 静电纺丝纤维支架高度模拟天然细胞外基质的纤维结构，具有比表面积大、孔隙率可控、生物性能良好等特点，有益于加速创面愈合，又可减少瘢痕形成，常用于组织修复与再生，是可降解伤口敷料领域的重要发展方向。本文对静电纺丝纤维敷料应用在伤口愈合及抑制瘢痕形成的研究现状进行综述，重点介绍了纤维支架材料和装载活性药物的研究进展，最后探究了载药/细胞纤维支架的应用潜力并对其未来发展方向进行展望。

Abstract:: Electrospun fibrous scaffold highly simulates the fiber structure of nature extracellular matrix, with large surface area, controllable porosity and superior biological property, which are beneficial to promote wound healing and prevent scar forming. It is widely applied in tissue regeneration, representing an important direction in the development and fabrication of degradable wound dressings. We review the research progress on the application of electrospun nanofiber dressings in wound healing and scarring prevention，mainly introduce the research progress of fibrous scaffold materials and bioactive drug loading. Finally, the application potential of drug/cell-loaded fibrous scaffold is discussed and its future developing direction is prospected.