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Title:: Influence of H1 transcranial magnetic stimulation coil structure design on stimulation effect

作者:: 吴雅祥1; 廖绍伟1△; 刘仲武2△; 余红雅2; （1. 华南理工大学电子与信息学院，广州 510641；2. 华南理工大学材料科学与工程学院，广州 510641）

Author(s):: WU Yaxiang1; LIAO Shaowei1; LIU Zhongwu2; YU Hongya2; （1.School of Electronic and Information Engineering, South China University of Technology, Guangzhou 510640, China; 2. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640）

Keywords:: Transcranial magnetic stimulation; H1 coil; Coil structure; Stimulation depth

摘要:: 经颅磁刺激（transcranial magnetic stimulation, TMS）是一种无创、无痛、低成本实现大脑刺激的工具，在治疗许多精神疾病方面有效。H1型线圈是一种TMS线圈。为实现深部脑组织刺激，基于现有的H1型线圈，本研究提出一种由四匝线圈组成的一种简化的H形线圈，使用有限元分析计算球形头部模型内电场分布，并利用大脑内深度20 mm处最大的电场强度E_max(20)与大脑表面最大电场强度E_max(0)的比值P(20)和E_max(0)研究H形线圈结构设计对刺激深度的影响。分析结果表明， H形线圈的刺激效果由线圈中两组线圈的结构、位置共同决定，通过调整线圈结构，最优的H1线圈对应的P(20)和E_max(0)分别为75.54%和32.97 V/m。通过合理的结构设计，可实现在大脑表面最大电场强度较小的同时，刺激颅内深部组织。

Abstract:: Transcranial magnetic stimulation (TMS) is a non-invasive, painless, low-cost tool in brain stimulation, and has been effective in treating many mental disorders. The H1 coil is a promising tool to achieve deep brain tissue stimulation, which is beneficial for various diseases treatment caused by deep brain tissue lesions. Based on the commercial H1 coil, we proposed a simplified H-shaped coil composed of four turns. Finite element analysis was used to calculate the E field distribution in the spherical head model, the maximum electric field intensity at the depth of 20 mm in the brain and on the brain surface were noted as E_max(20) and E_max(0), separately. The proportion of E_max(20) in E_max(0) was used to characterize the influence of coil structure modification on stimulation depth. Simulation result revealed that, the H-shaped coil′s stimulation effect was determined by both the structure and position of the two sets of coils. By adjusting the coil structure, the optimized H1 coil, P(20) and E_max(0) were 75.54% and 32.97 V/m, respectively. It is possible to stimulate deep intracranial tissues through reasonable structural design while minimize the maximum electric field intensity on the brain surface.