[1]朱肖杰,孟建文△,朱小敏,等.淀粉-海藻酸盐复合止血材料的制备及性能研究*[J].生物医学工程研究,2021,04:395-400.
ZHU Xiaojie,MENG Jianwen,ZHU Xiaomin,et al.Preparation and properties of alginate composite hemostatic materials[J].Journal of Biomedical Engineering Research,2021,04:395-400.
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淀粉-海藻酸盐复合止血材料的制备及性能研究*(PDF)
《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
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2021年04期
- 页码:
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395-400
- 栏目:
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- 出版日期:
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2021-12-25
文章信息/Info
- Title:
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Preparation and properties of alginate composite hemostatic materials
- 文章编号:
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1672-6278 (2021)04-0395-06
- 作者:
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朱肖杰1; 孟建文1△; 朱小敏1; 罗西友1; 张素文1; 马学彬1; 杨忠波2△
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1. 山东省药学科学院,山东省医用高分子材料重点实验室,济南 250101;2. 山东黄河河务局山东黄河医院,济南 250032
- Author(s):
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ZHU Xiaojie1; MENG Jianwen1; ZHU Xiaomin1; LUO Xiyou1; ZHANG Suwen1; MA Xuebin1; YANG Zhongbo2
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1.Shandong Academy of Pharmaceutical Sciences,Shandong Provincial Key Laboratory of Biomedical Polymers,Jinan 250101,China;2.Shandong Yellow River Hospital, Yellow River Shandong Bureau,Jinan 250032
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- 关键词:
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马铃薯淀粉; 海藻酸钠; 反相乳液; 吸液能力; 体外止血; 动物实验; 创面凝血
- Keywords:
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Potato starch; Sodium alga acid; Inverse emulsion; Liquid absorption capacity; In vitro coagulation; Animal experiment; Wound clotting
- 分类号:
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R318;O636
- DOI:
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10.19529/j.cnki.1672-6278.2021.04.09
- 文献标识码:
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A
- 摘要:
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本研究采用反相乳液法,制得淀粉-海藻酸盐复合止血材料。通过扫描电镜、吸液性能测试、体外凝血试验和大鼠肝脏止血试验对其物理形貌、吸液性能,体外凝血性能、动物止血效果进行研究。结果表明,淀粉-海藻酸盐复合止血材料表面呈粗糙、多孔状,对模拟体液的吸液倍率可达20~22倍。体外凝血试验中,淀粉-海藻酸盐复合止血材料的全血凝固时间比空白缩短了28.65%。大鼠肝脏止血试验,相对模型组止血时间缩短57.9%,出血量减少64.3%,在外科手术创面止血有着良好的应用前景。
- Abstract:
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Starch-alginate composite hemostatic material was prepared by inverse emulsion method.The morphology, extracorporeal coagulation and hemostatic effect in animal experiments were studied by scanning electron microscopy, fluid absorption performance, 〖WTBX〗in vitro〖WTBZ〗 coagulation test and rat liver hemostatic test. The results showed that the surface of starch-alginate composite hemostatic material was rough and porous, and the absorption rate of simulated body fluid reached 20~22 times.〖WTBX〗In vitro〖WTBZ〗 coagulation test, the coagulation time of blood was shorter 28.65% than that of blank test.Compared to model group, the hemostatic time of rat liver was reduced by 57.9% and the amount of blood loss was reduced by 64.3%. Therefore, the starch-alginate composite hemostatic material has a good application prospect in surgical wound hemostasis.
备注/Memo
- 备注/Memo:
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(收稿日期:2021-03-20)山东省重点研发计划项目(2018GSF118052)。△通信作者Email:9724088@qq.com;cnsdhhh@163.com
更新日期/Last Update:
2022-01-17