|本期目录/Table of Contents|

[1]洪肖,尚振东△,李兆颖,等.皮下注射疼痛指数的仿真研究*[J].生物医学工程研究,2022,03:275-284.
 HONG Xiao,SHANG Zhen dong,LI Zhaoying,et al.Simulation study of pain index for subcutaneous injection[J].Journal of Biomedical Engineering Research,2022,03:275-284.
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皮下注射疼痛指数的仿真研究*(PDF)

《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年03期
页码:
275-284
栏目:
出版日期:
2022-09-25

文章信息/Info

Title:
Simulation study of pain index for subcutaneous injection
文章编号:
1672-6278 (2022)03-0275-10
作者:
洪肖1尚振东2△李兆颖1魏钦章1胡志刚3
1.河南科技大学 机电工程学院,洛阳 471003;2.河南科技大学协同创新中心,洛阳 471003;3.河南科技大学 医学技术与工程学院,洛阳 471003
Author(s):
HONG Xiao1 SHANG Zhen dong2 LI Zhaoying1 WEI Qinzhang1 HU Zhigang3
1. School of Mechanical and Electrical Engineering, Henan University of Science and Technology, Luoyang 471003,China; 2.Collaborative Innovation Center, Henan University of Science and Technology, Luoyang 471003;3.College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 47100
关键词:
缓解刺激两相流生物力学相分布达西定律多孔弹性介质网格划分
Keywords:
Stimulation mitigation Two-phase flow Biomechanics Phase distribution Darcy’s law Pporous elastic media Meshing
分类号:
R318.01;TP391.9;Q811.21
DOI:
10.19529/j.cnki.1672-6278.2022.03.09
文献标识码:
A
摘要:
为减轻病患皮下注射治疗的痛苦,实现精准医疗,研究皮下注射速度与疼痛指数(PDI)间的关系。本研究采用有限元仿真方法,通过建立人体软组织皮下注射仿真模型,利用流体力学和组织生物力学原理,模拟药物的注射过程中引起的组织变形及压力变化,得到不同注射剂量下的最优注射速度。结果表明,疼痛指数与皮下注射药物过程中所引起的组织压力变化和组织形变有关,随着药物剂量的增加,人体组织的压力和形变随之增加,在注射剂量一定的情况下,注射时组织产生的压力随着注射速率的增加而增加,而随着扩散距离的增大逐渐趋近于零;在一定剂量下,PDI随注射速度的增大先快速下降,至最小值后平缓上升。其中最小值对应的注射速率为当前剂量下的最优速度。随着注射剂量的增加,最优速度也逐渐增大。在进行药物皮下注射时,当确定注射剂量后,选择该剂量下的最优速度进行注射,可使患者的疼痛感最小。
Abstract:
In order to alleviate the pain of subcutaneous injection and achieving precision therapy, and to study the relationship between subcutaneous injection speed and pain dispersion index (PDI),We used the finite element simulation method to establish the simulation model of subcutaneous injection of human soft tissue.The principles of fluid mechanics and tissue biomechanics were used to simulate the tissue deformation and pressure change caused by drug injection process, the optimal injection speed under different injection doses was obtained. Pain index was related to the change of tissue pressure and tissue deformation caused by the process of subcutaneous injection of drugs, with the increase of drug dose, the pressure and deformation of human tissues increased, in the case of a certain injection dose, the pressure generated by the tissue during injection increased with the increase of injection rate, and gradually approached zero with the increase of diffusion distance; at a certain dose, PDI decreased rapidly with the increase of injection speed, dropped to the minimum value and then rised smoothly. The injection rate corresponding to the minimum was the optimal rate for the current dose. As the injection dose increased, the optimal speed gradually increased. When performing subcutaneous injection of drugs, with the injection dose determined, the optimal speed under the injection can be selected to minimize the pain of the patient.

参考文献/References

备注/Memo

备注/Memo:
(收稿日期:2022-03-22)河南省科技攻关计划项目(192102310454,192102210141);河南省高等学校青年骨干教师资助计划项目(2019GGJS082)。△通信作者Email:cnlyszd@163.com
更新日期/Last Update: 2022-11-08