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Title:: The influence of incidence angle on local deposition rate of asthma drug particles in human respiratory tract

Author(s):: FENG Sen; YAN Sixin; CUI Biao; ZHANG Zhiguo; （College of Mechanical and Electronic Engineering, Hohai University, Changzhou 213002, China）

Keywords:: Asthma; Drug particles; Incidence angle; Deposition rate; Computational fluid dynamics

摘要:: 为探究入射角度与哮喘药物颗粒局部沉积之间的相关性，本研究采用计算流体动力学方法对入射角度进行数值分析。首先，基于哮喘患者的CT数据，重建气雾剂吸入过程时近生理的瞬态计算力学模型；然后，运用计算流体动力学-离散相模型定量化分析入射角度对药物颗粒在呼吸道局部沉积率的影响。结果表明，哮喘药物颗粒在口腔及肺部沉积较多，在咽腔、喉腔及G0-G5支气管沉积较少；随着入射角度的增大，颗粒在口腔的沉积率呈先降低后升高趋势，在咽腔、喉腔、支气管及肺部的沉积率则呈先升高后降低趋势。本研究可为下气道靶向给药策略提供重要的理论依据，从而选择最佳给药策略。

Abstract:: In order to investigate the correlation between the incidence angle and the local deposition of asthma drug particles, we used computational fluid dynamics method to numerically analyze the incident angle. Firstly, based on the CT data of asthma patients, the near physiological transient computational biomechanical model of aerosol inhalation was reconstructed. Then, the effect of incident angle on the local deposition rate of drug particles in the respiratory tract was quantitatively analyzed by using computational fluid dynamics discrete phase model. The research showed that the deposition of asthma drug particles was more in the mouth and lungs, but less in the pharynx, larynx and G0-G5 bronchus. With the increase of particles’ incidence angles, the deposition fraction in the oral cavity decreased firstly and then increased, the deposition fraction in the pharynx, larynx, bronchus and lung showed a trend of increased firstly and then decreased. The results can provide important theoretical basis for lower airway targeted drug delivery strategy, so as to select the optimal drug delivery strategy.