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Title:: Numerical simulation for embolus extraction from vertebrobasilar artery

Author(s):: LUO Ziyi; QIU Xue; CHENG Yunzhang; （School of Health Science and Engineering, University of Shanghai for Science and Technology,Shanghai 200093，China）

Keywords:: Interventional therapy; Vascular emulation; Computational fluid dynamics; Finite element analysis; Direct aspiration thrombectomy; VBA

摘要:: 为探究椎基底动脉抽吸取栓的血流动力学机制，本研究结合临床数据和计算流体力学，对血管模型进行抽吸取栓的流固耦合数值仿真，观察抽吸取栓效果。通过设定不同的入口压力，仿真不同抽吸压力下，抽吸取栓对血管的影响。结果显示，随着抽吸压力增大，等效应力、血管壁面剪切应力（wall shear stress，WSS）和形变量均呈增大趋势。结果表明，抽吸取栓对血管的损伤和其压力呈正相关。本研究可为抽吸取栓的压力设计提供血流动力学理论依据。

Abstract:: In order to explore the hemodynamic mechanism of vertebrobasilar artery emboli aspiration, we combined clinical data and computational fluid dynamics to conduct fluid-structure coupling numerical simulation of aspiration thrombus on the vascular model and observe the effect of aspiration thrombus. The effect of suction plug on blood vessels under different suction pressure was simulated by setting different inlet pressure. The results showed that the equivalent stress, wall shear stress (WSS) and shape variable increased with the increase of suction pressure. The results indicated that the damage to blood vessels caused by embolus extraction was positively correlated with the suction pressure. It can provide a theoretical basis of hemodynamics for the pressure design of embolus extraction.