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Title:: A method for preparing polyvinyl alcohol microspheres with controllable particle size based on liquid jet breakup

作者:: 赵培1; 2; 许珂1; 2; 吴迪1; 2; 黄琳静1; 2; 杨志强1; 2; 邹方明1; 2; 赵成如1; 2; 夏毅然1; 2△; （1.赛克赛斯生物科技股份有限公司，济南 250101；2.生物医用材料山东省工程研究中心，济南 250101）

Author(s):: ZHAO Pei 1; 2; XU Ke 1; 2; WU Di 1; 2; HUANG Linjing 1; 2; YANG Zhiqiang 1; 2; ZOU Fangming1; 2; ZHAO Chengru 1; 2; XIA Yiran 1; 2; （1. Success Bio-Tech Co., Ltd., Jinan 250101, China; 2. Biomedical Materials Engineering Research Center of Shandong Province, Jinan 250101）

Keywords:: Interventional embolization; Liquid jet breakup; polyvinyl alcohol microspheres; Feeding device; Particle size distribution

摘要:: 在工业生产中，聚乙烯醇（polyvinyl alcohol，PVA）微球多采用机械搅拌法制备，得到的微球粒径不可控、粒径分布宽、小粒径（100~300 μm）微球产率低。为改善上述问题，本研究将液体射流破碎法应用于油包水（W/O）微球制备体系，制备了粒径可控、粒径分布窄的PVA水凝胶微球。本研究系统研究了分散相流速、PVA浓度、加料装置内径及稳定剂浓度对微球粒径和粒径分布的影响。最终，采用分散相流速为40 mL/min、PVA浓度为7.0%、加料装置内径为400 μm及稳定剂浓度为11.5%的条件，制备了平均粒径为146.00 μm，粒径分布为1.63的PVA微球。该方法得到的小粒径微球产率高、批次间重复性良好、装置简单，可实现微球的规模化生产。

Abstract:: In the industrial production, polyvinyl alcohol (PVA) microspheres are mostly prepared by mechanical stirring method, resulting in uncontrollable particle size, wide particle size distribution and low yield of small particle size (100~300 μm) microspheres.To improve these issues, PVA hydrogel microspheres with controlled particle size was prepared by liquid jet breakup method. The processing conditions, dispersed phase flow rate, PVA concentration, diameter of the feeding device and the stabilizer concentration were optimized to fabricate PVA microspheres. Finally, the PVA microspheres with an average particle size of 146.00 μm and size distribution coefficient of 1.63 were successfully fabricated by using 400 μm feeding device under the dispersed phase flow rate of 40 mL/min, the dispersed phase concentration of 7.0%, and the stabilizer concentration of 11.5%. This method improves the yield of small particle size microspheres, has good repeatability between batches, which can realize large-scale production of microspheres.