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Title:: Event-related potential N450 study on excitement and inhibition in conflict monitoring

Author(s):: WANG Aili; JIA Meixue; SUI Li; （School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China）

摘要:: 为探讨健康人执行Stroop变式（字义-时长）任务时，冲突监控过程中兴奋与抑制对事件相关电位N450的影响。本研究选取了46名本科生随机分配至时长估计任务组（n=22）和一致性判断任务组（n=24），分别诱发字义的抑制及字义的兴奋与抑制，对两组在两种条件下（字义-时长判断冲突与不冲突）的行为数据和事件相关电位N450进行研究。结果发现：（1）两组冲突条件下，反应时显著增加；在时长估计任务组中，冲突条件下正确率显著下降(P<0.05）；（2）仅诱导字义的抑制，冲突与不冲突条件下N450波幅无显著差异；同时诱导字义的抑制与兴奋，冲突与不冲突条件下N450波幅有显著差异（P<0.05）；（3）sLORETA溯源结果表明，冲突处理与扣带回和额顶叶网络被激活有关。研究表明，刺激冲突时被试的反应会受到显著影响，事件相关电位N450与刺激的兴奋与抑制过程有关。

Abstract:: To investigate the effects of excitation and inhibition on N450 during conflict monitoring in healthy subjects doing the Stroop variant (word sense-duration task). 46 undergraduate students were chosen and randomly assigned to the duration estimation task group(n=22) and the consistency judgment task group(n=24). Inhibition vs. excitation and inhibition were then induced in word sense, respectively. Event-related potentials (ERPs) N450 were then researched in both groups under the conditions between word sense and duration judgment the conflict and non-conflict. The results showed that:（1）In the conflict condition, reaction times significantly increased in both groups; meanwhile, the duration estimation task group′s correct rate dramatically fell(P<0.05); （2）There was a significant variation in the amplitude of the N450 wave under the two conditions when word sense inhibition and excitation were induced simultaneously（P<0.05); （3）The sLORETA trace data showed that conflict processing was linked to both frontoparietal network and cingulate gyrus activation. The study indicates that the excitatory and inhibitory components of the stimulus have an impact on both the event-related potential N450 and the reactions of the subjects during stimulus conflict.