|本期目录/Table of Contents|

[1]高蔷,王龙飞,邓林红△,等.基于PDMS微结构的气道平滑肌舒张药物评测装置*[J].生物医学工程研究,2021,03:312-317.
　GAO Qiang,WANG Longfei,DENG Linhong,et al.Development of a PDMS-microstructure based device for the assessment of airway smooth muscle relaxants[J].Journal of Biomedical Engineering Research,2021,03:312-317.
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基于PDMS微结构的气道平滑肌舒张药物评测装置*(PDF)

《生物医学工程研究》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2021年03期
页码:
312-317
栏目:
出版日期:
2021-09-25

文章信息/Info

Title:
Development of a PDMS-microstructure based device for the assessment of airway smooth muscle relaxants
文章编号:
1672-6278 (2021)03-0312 -06
作者:
高蔷;  王龙飞;  邓林红△;  王翔△
常州大学生物医学工程与健康科学研究院，常州 213164
Author(s):
GAO Qiang;  WANG Longfei;  DENG Linhong;  WANG Xiang
Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China
关键词:
哮喘; 气道平滑肌细胞; 细胞力学; PDMS微结构; 舒张
Keywords:
Asthma; Airway smooth muscle cells; Cellular mechanics; PDMS microstructure; Relaxation
分类号:
R318
DOI:
DOI10.19529/j.cnki.1672-6278.2021.03.15
文献标识码:
A
摘要:
本研究设计并制备了一种基于PDMS微弦结构的细胞力学测量装置。将平滑肌微组织培养在该柔性微型传感器上，通过检测PDMS微结构因微组织牵拉作用而产生的形变，实现了对其收缩力动态的测量。利用临床抗哮喘药物，我们验证了该装置的灵敏度和可靠性。该方法的建立将将有助于未来筛选平滑肌舒张作用药物。
Abstract:
We developed a cell mechanics measurementdevicebased on PDMS microstructure. After the smooth muscle microtissueswere cultivated on the flexible microstrings, we calculated the dynamic contractile force by measuring the deformation of the PDMS microstructure underthe contraction of the microtissues. The clinical anti-asthma drugs were used to verify the sensitivity and reliability of the device. The establishment of this method will helpto screen smooth muscle relaxation drugsinthe future.

参考文献/References

备注/Memo

备注/Memo:
（收稿日期：2021-01-06）国家自然科学基金资助项目(31670950,11532003,31972922)；江苏省自然科学基金资助项目(BK20191452)。△通信作者Email:wangxiang@cczu.edu.cn；dlh@cczu.edu.cn
更新日期/Last Update: 2021-11-01